Vitreal Oxygenation in Retinal Ischemia Reperfusion
نویسندگان
چکیده
منابع مشابه
Vitreal oxygenation in retinal ischemia reperfusion.
PURPOSE To study the feasibility of anterior vitreal oxygenation for the treatment of acute retinal ischemia. METHODS Twenty rabbits were randomized into an oxygenation group, a sham treatment group, and a no treatment group. Baseline electroretinography (ERG) and preretinal oxygen (Po(2)) measurements were obtained 3 to 5 days before surgery. Intraocular pressure was raised to 100 mm Hg for ...
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Tissue hypoxia has been demonstrated, in both the renal cortex and medulla, during the acute phase of reperfusion after ischemia induced by occlusion of the aorta upstream from the kidney. However, there are also recent clinical observations indicating relatively well preserved oxygenation in the nonfunctional transplanted kidney. To test whether severe acute kidney injury can occur in the abse...
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METHODS. Intraocular pressure of adult male Lewis albino rats was raised to create retinal ischemia for 1 hour. Retinal reperfusion was reestablished, and the animals were killed at various time points after the injury. Their eyes were enucleated and processed for immunohistochemistry to detect IL-6 and ED-1 (a marker of microglial/phagocytic cells), enzyme-linked immunosorbent assay (ELISA) of...
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PURPOSE To investigate whether lipid peroxides play a role in retinal cell death due to ischemia-reperfusion injury, whether recombinant human thioredoxin (rhTRX) treatment reduces production of lipid peroxides of the retina, and whether such treatment reduces the number of cells expressing c-Jun and cyclin D1. METHODS Retinal ischemia was induced in rats by increasing the intraocular pressur...
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METHODS. Retinal ischemia–reperfusion injury was performed on p55 and p75 knockout (KO) mice and Sprague–Dawley rats using the high intraocular pressure method. The temporal expression of TNFwas ascertained with immunohistochemical staining. Separate rats received intravitreal recombinant TNFor neutralizing antibody before or after ischemia. TUNEL labeling was performed to assess for cell death...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2011
ISSN: 1552-5783
DOI: 10.1167/iovs.09-4516